重庆医学2016，Vol.45Issue(9)：1228-1232,5.DOI:10.3969/j.issn.1671-8348.2016.09.023
乳腺癌17号染色体异倍体对HER-2表达的影响及临床病理学意义
Impact of chromosome 17 heteroploid of breast cancer on HER-2 expression and its clinicopathologic significance
张文进 1刘月平 2李云涛 1吴雅轩 1耿翠芝1
作者信息
- 1. 河北医科大学第四医院外一科，石家庄050035
- 2. 河北医科大学第四医院病理科，石家庄050035
- 折叠
摘要
Abstract
Objective To investigate the impact of chromosome 17 heteroploid (polysomy ,haploid) of breast cancer on the expression of human epidermal growth factor receptor 2(HER‐2) and its clinicopathologic significance .Methods A total of 352 cases of invasive breast cancer were collected from January to December 2013 .The expression of HER‐2 was detected by simultane‐ously using the fluorescent insituhybridization(FISH) and mimunohistochemistry .The cases were divided into the groups according to the chromosome 17 polysomy ,haploid and the expression of HER‐2 .The clinicopathological features were analyzed and compared among groups .Results The chromosome 17 polysomy and haploid had no correlation with HER‐2 protein expression(P>0 .05);chromosome 17 polysomy was negatively correlated with HER‐2 gene amplification(r= -0 .162 ,P=0 .001);chromosome 17 hap‐loid was positively correlated with HER‐2 gene amplification(r=0 .282 ,P=0 .000) .Compared with the HER‐2‐negative group ,the chromosome 17 polysomy group had a statistically significant difference in histological grade and vascular tumor thrombus (P<0 .05) .Compared with the HER‐2‐positive group ,the chromosome 17 polysomy group had a statistically significant difference in histological grade ,vascular tumor thrombus ,Ki‐67 expression ,ER positive expression and PR positive expression (P<0 .05) .Com‐pared with the HER‐2‐negative group ,the chromosome 17 haploid group had a statistically significant difference in PR positive ex‐pression (P<0 .05) .The tumor diameter in the chromosome 17 haploid group had a statistically significant difference compared with the HER‐2‐positive group(P<0 .05) .Compared with the chromosome 17 haploid group ,the chromosome 17 polysomy group had a statistically significant difference in vascular tumor thrombus and PR positive expression(P<0 .05) .Conclusion The chro‐mosome 17 polysomy and haploid have no correlation with the HER‐2 protein expression ,but associated with HER‐2 gene amplifi‐cation .The chromosome 17 polysomy group has unique clinicopathological features ,which may indicate the prognosis in the patients with breast cancer .关键词
乳腺肿瘤/人表皮生长因子受体-2/17号染色体多体/17号染色体单体Key words
breast neoplasms/HER-2/chromosome 17 polysomy/chromosome 17 haploid分类
医药卫生引用本文复制引用
张文进,刘月平,李云涛,吴雅轩,耿翠芝..乳腺癌17号染色体异倍体对HER-2表达的影响及临床病理学意义[J].重庆医学,2016,45(9):1228-1232,5.
