重庆医学2016，Vol.45Issue(9)：1233-1235,1239,4.DOI:10.3969/j.issn.1671-8348.2016.09.024
氨甲环酸与纤维蛋白胶在关节置换术后疗效比较的 Meta分析
Comparison of effect between tranexamic acid versus fibrin sealant after joint arthroplasty:a Meta-analysis
摘要
Abstract
Objective To compare the effectiveness and safety of tranexamic acid and fibrin sealant in joint arthroplasty . Methods The literatures on the application of tranexamic acid and fibrin sealant in joint arthroplasty were retrieved from PubMed , Embase ,Cochrane Library ,CNKI and other internet databases .Two reviewers independently screened the literatures according to the inclusion and exclusion standard .The RevMan 5 .2 software was adopted to conduct the statistical analysis on the extracted da‐ta .Results Four randomized controlled trials(RCTs) and 2 retrospective experiments were included ,involving 449 patients .The meta analysis results showed that tranexamic acid and fibrin sealant had no statistically significant difference in total blood loss[MD= -192 .24 ,95% CI(-496 .16 ,111 .69) ,P=0 .22] and hemoglobin loss amount[MD= -0 .49 ,95% CI(-1 .19 ,0 .20) ,P=0 .16] , had statistically significant difference in the blood transfusion rate[OR=0 .30 ,95% CI(0 .18 ,0 .52) ,P<0 .01] ,and had no statisti‐cally significant difference in the postoperative complications[OR=1 .20 ,95% CI(0 .36 ,3 .99) ,P=0 .76] .Conclusion Tranexamic acid is more effective than fibrin sealant of controlling postoperative transfusion rate in joint arthroplasty .关键词
关节成形术 ,置换/氨甲环酸/纤维蛋白胶/Meta分析Key words
arthroplasty ,replacement/tranexamic acid/fibrin sealant/Meta-analysis分类
医药卫生引用本文复制引用
饶烽,丁浩,王琰,陈福宇,史晨辉,王维山..氨甲环酸与纤维蛋白胶在关节置换术后疗效比较的 Meta分析[J].重庆医学,2016,45(9):1233-1235,1239,4.基金项目
国家自然科学基金资助项目（81160225，81260453，81360451）；新疆兵团医药卫生专项资助（2013BA020）；兵团国际交流与合作专项资助（2012BC002，2011BC004）；兵团科技创新团队专项基金（2014CC002）。 （）
