重庆医学2016，Vol.45Issue(9)：1240-1243,1248,5.DOI:10.3969/j.issn.1671-8348.2016.09.026
中国先天性心脏病危险因素的Meta分析
Risk factors of congenital heart diseases in China:a Meta-analysis
摘要
Abstract
Objective To analyze the risk factors of congenital heart disease(CHD) in China by using the meta‐analysis method to provide reference for etiology study and prevention of CHD .Methods The Chinese literature database such as CBM , VIP ,CNKI ,Wan Fang were retrieved from 2005 to 2015 for collecting the related literatures ,then the collected literatures were screened ,performed the information extraction ,quality evaluation and merged analysis by using the Stata12 .0 software .Results In this study ,37 articles were included ,including 20 provinces (municipalities and autonomous regions) ,8 588 cases in the case group and 12 479 cases in the control group;a total of 21 risk factors(5 pre‐pregnant factors and 16 gestational factors) were included . Conclusion All 21 risk factors include 4 pre‐pregnancy factors ,15 gestational factors and 2 factors which not be verified .The top 3 risk factors and their OR values with 95% CI were gestational diabetes 5 .80(2 .72-12 .37) ,contacting the occupational risk factors 5 .14(3 .30-8 .00) ,advanced age before pregnancy 4 .96(1 .45-16 .97) .Not considering to be as the risk factors and their OR value with 95% CI are high body mass index before pregnancy 1 .32(0 .99 -1 .75) ,living near street during pregnancy 1 .36(0 .50-3 .71 ) .关键词
先天性心脏病/危险因素/病例对照/Meta分析Key words
congenital heart disease/risk factors/case-control/Meta-analysis分类
医药卫生引用本文复制引用
周天津,罗亚玲,周雪晴,万素馨..中国先天性心脏病危险因素的Meta分析[J].重庆医学,2016,45(9):1240-1243,1248,5.基金项目
2015年国家社会科学基金项目（15BGL191）；重庆市渝中区科技规划项目（20110403）。 （）
