解放军医药杂志2016，Vol.28Issue(3)：81-84,4.DOI:10.3969/j.issn.2095-140X.2016.03.019
四君子汤联合肠内营养乳剂对肝硬化肝癌大鼠肝部分切除后免疫功能与营养状态的影响
Effects of Sijunzi Decoction Combined with Enteral Nutrition Emulsion on Immune Function and Nutritional Sta-tus of Rats with Hepatic Cirrhosis and Hepatic Carcinoma after Partial Hepatectomy
摘要
Abstract
Objective To study the effects of Sijunzi decoction combined with enteral nutrition emulsion on im-mune function and nutritional status of rats with hepatic cirrhosis and hepatic carcinoma after partial hepatectomy. Meth-ods A total of 112 rats were selected and models were successfully established for hepatic cirrhosis and hepatic carcino-ma, and they were randomly divided into observation group ( n=56 ) and control group ( n=56 ) . The rats underwent partial hepatectomy using Higgins method. The control group received enteral nutrition emulsion and physiological saline based on regular diet, while the observation group was added with Sijunzi decoction based on regular diet and enteral nu-trition emulsion. Changes of immune function and nutritional status before and after operation were compared in the two groups. Results Compared with those in the control group, the levels of hemoglobin ( Hb) , total cholesterol ( TC) , tri-glyceride ( TG) and low density lipoprotein ( LDL) were significantly higher in observation group 7 d after the operation (P<0. 05, P<0. 01); on 7 d after the operation in the two groups, the postoperative concentrations of CD3, CD4, IgG, IgM and IgA and CD4/CD8 value were significantly lower, while the CD8 concentrations were significantly higher than those before the treatment (P<0. 01); in the observation group, the postoperative concentrations of CD3, CD4, IgG, IgM and IgA and CD4/CD8 value were significantly higher, while the CD8 concentration was significantly lower than those in the control group (P<0. 05, P<0. 01). Conclusion Intragastric administration of enteral nutrition emul-sion and Sijunzi Decoction can help to improve the immune function and nutritional status of rats with hepatic cirrhosis and hepatic carcinoma after partial hepatectomy and provide certain theoretical basis for clinical practice.关键词
肝硬化/肝癌/肠内营养/四君子汤/营养状况/免疫功能/大鼠,WistarKey words
Liver cirrhosis/Liver neoplasms/Enteral nutrition/Sijunzi decoction/Nutritional status/Immune function/Rats, Wistar分类
中医学引用本文复制引用
金国贤,曲晓翰,郭庆,孙英伟,邵丽春..四君子汤联合肠内营养乳剂对肝硬化肝癌大鼠肝部分切除后免疫功能与营养状态的影响[J].解放军医药杂志,2016,28(3):81-84,4.基金项目
辽宁省自然科学基金项目(2011225019) （2011225019）
