化工进展2016，Vol.35Issue(4)：971-980,10.DOI:10.16085/j.issn.1000-6613.2016.04.001
生物过程工程研究在创新生物医药开发中应用的驱动力--生物反应器
Pioneering application of biological process engineering in innovative bio-pharmaceutical development--bioreactors
摘要
Abstract
In recent years,the proportion of innovative biomedical in the biotechnology industry has been increasing gradually,which is mainly due to the improvement of upstream technology such as target screening and molecule construction and brings tremendous economic benefit. With the increasing applications of cell culture technology in biomedical industry,demand for its innovation has been increasing. And so it is with the equipment bioreactors. This review introduced the categories, development trend and driving force of bioreactors in biomedical industry. The achievements of novel bioreactors including the applications of novel bioreactor technology and process analytical technology are also summarized. Finally,we discussed the development status and problems of bioreactor industry in China and pointed out that increasing the product quality rather than production is the goal of bioreactor development. This review also expounded the key role of modern bioreactor technology and the “Quality by Design”principles of ,as well as the developmenet status and trend of bioreactor technology.关键词
生物反应器/生物过程工程/质量源于设计/过程分析技术/创新生物医药/生物工程/微反应器Key words
bioreactor/biological process engineering/quality by design/PAT/innovative bio- pharmaceutical/biological engineering/microreactor分类
生物工程引用本文复制引用
孙杨,聂简琪,刘秀霞,杨艳坤,戴晓峰,白仲虎..生物过程工程研究在创新生物医药开发中应用的驱动力--生物反应器[J].化工进展,2016,35(4):971-980,10.基金项目
国家高技术研究发展计划（2015AA020802）及中央高校基本科研业务费专项资金（JUSRP51401A）项目。 （）
