聊城大学学报（自然科学版）2016，Vol.29Issue(1)：37-42,6.
L-丝氨酸水杨醛希夫碱镍（Ⅱ）配合物的合成、结构及与 DNA 的相互作用
Synthesis,Structure and DNA Interaction of a NickeI (Ⅱ) CompIex with Schiff Base of L-Serine and SaIicyIaIdehyde
摘要
Abstract
A new nickel(II) complex ,[Ni(ser‐sal)(phen)(CH3 OH)] (ser‐sal = Schiff base derived from L‐serine and salicylaldehyde ,phen=1 ,10‐phenanthroline) ,has been synthesized and characterized by IR spectrum and elemental analyses .The crystal structure has been determined by single crystal X‐ray diffraction a‐nalysis .It showed that the complex belongs to monoclinic crystal system ,C2/c space group with the cell parameters :a=26 .040(2) Å ,b=15 .110 1(13) Å ,c=11 .592 0(9) Å ,α=90° ,β=107 .128(2)° ,γ=90° ,V =4 358 .8(6) Å3 ,Z=8 , F(000)=1 984 ,R1 =0 .078 5 ,w R2 =0 .204 0 .In the crystal ,a 2D net‐work structure was formed by intermolecular hydrogen bonds .The interaction of the nickel(Ⅱ ) com‐plex with calf thymus DNA (CT‐DNA) has been studied by UV absorption ,fluorescence and circular di‐chroism(CD) spectra .The results indicate that the complex can bind to CT‐DNA in a intercalative mode with a binding constant Kb of 7 .8 × 104 L · mol-1 and a fluorescence quenching constant Ksq of 0 .91 .关键词
镍(Ⅱ)配合物/L-丝氨酸/希夫碱/晶体结构/DNAKey words
nickel (II) complex/L-Serine/Schiff base/crystal structure/DNA分类
化学化工引用本文复制引用
丁菲菲,丁名成,魏强,李连之..L-丝氨酸水杨醛希夫碱镍（Ⅱ）配合物的合成、结构及与 DNA 的相互作用[J].聊城大学学报（自然科学版）,2016,29(1):37-42,6.基金项目
山东省自然科学基金项目（Y2004B02）；聊城大学大学生科技文化创新基金（SF2014042）资助 （）
