摘要
Abstract
Objective To compare the efficacy and safety of Atosiban and βreceptor agonist in patients with preterm birth. Methods The databases of Pubmed, Cochrane Central Register of Controlled Trials, and CNKI were retrieved with computers for collecting randomized controlled trials ( RCTs) about the comparison in the efficacy and safety of atosiban andβreceptor agonist published during January 1990 and December 2014. At the same time, the reference materials of included literature were retrieved manually. After rigorous evaluation on literature quality, the eligible data of RCTs was extracted and given a meta-analysis using applying Rev Man 5. 0 software. Results There were totally 7 RCTs included, and the results of meta-analysis showed that between atosiban and β receptor agonist groups, the incidence rate of pregnancy extended to 48 h and 7 d, neonatal birth gestational age, birth weight had no statistical significance, and for the delivery rate within 48 h to 7 d without drug and other tocolytic agents, Atosiban group was better than beta agonists group [RR=1. 07, 95% CI (1. 00, 1. 14), P=0. 03;RR=1. 25, 95% CI (1. 14, 1. 38), P<0. 01];On clinical safety, Atosiban group was significantly low-er than the β agonists group in the incidence rate of maternal stop drug adverse reaction and matrix tachycardia [RR=0. 05, 95% CI(0. 03, 0. 10), P<0. 01;RR=0. 09, 95% CI (0. 01, 0. 17), P<0. 01]. Conclusion In the incidence rate of pregnancy extend to the 48 h, 7 d, in neonatal birth gestational age and birth weight, there is no statistical significance, but for the delivery rated without drug and need of other tocolytic agents, within 48 h and 9 d, Atosiban group is better than beta agonists group;On clinical safety, Atosiban group is significantly lower than theβagonists group in the incidence rate of ma-ternal stop drug adverse reaction and matrix tachycardia. The clinical superiority of Atosiban is preliminarily indicated.关键词
早产/阿托西班/肾上腺素能β受体激动剂/meta分析Key words
Preterm birth/Atoxiban/β receptor agonist/Meta analysis分类
医药卫生
