中国临床保健杂志2016，Vol.19Issue(2)：132-134,3.DOI:10.3969/J.issn.1672-6790.2015.02.006
非小细胞肺癌患者表皮生长因子受体突变与血清癌胚抗原和糖类抗原检测的关系
The relationship between epidermal growth factor receptor (EGFR)gene mutation and serum carcinoembry-onic antigen and carbohydrate antigen in patients with NSCLC
杨福利 1王继松 1牟坤 1黄振宇 1施明亮1
作者信息
摘要
Abstract
Objective To investigate the relationship between epidermal growth factor receptor (EGFR)gene mutation and carcino embryonie antigen (CEA),carbohydrate antigen (CA125,CA199)in patients with none small cell lung cancer (NSCLC)and explore prognostic values.Method 193 cases with NSCLC from January 2012 to January 2014 in the Laiwu People′s Hospital were selected,the preoperative serum levels of CEA,CA125,CA199 were detected and the relationship between the CEA,CA125,CA199 and EGFR gene mutation were analyzed.Result EGFR gene mutations were detected in 83 cases(43.0%);EGFR gene mutation were more commonly found in female,non-smokes and adenocarcinoma (P <0.05);EGFR gene mutation was positive correlated with CEA level(P <0.05);while there were no correlation between EGFR and CA125 /CA199(P >0.05).Conclusion EGFR gene mutation is more common-ly found in female,non-smokers and adenocarcinoma,which is related to the increased serum CEA level.关键词
癌,非小细胞肺/受体,表皮生长因子/癌胚抗原/CA-19-9 抗原/CA-125 抗原Key words
Carcinoma,non-small-cell lung/Receptor,epidermal growth factor/Carcinoembryonic antigen/CA-19-9 antigen/CA-125 antigen分类
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杨福利,王继松,牟坤,黄振宇,施明亮..非小细胞肺癌患者表皮生长因子受体突变与血清癌胚抗原和糖类抗原检测的关系[J].中国临床保健杂志,2016,19(2):132-134,3.
