中国临床保健杂志2016，Vol.19Issue(2)：138-140,225,4.DOI:10.3969/J.issn.1672-6790.2016.02.008
幽门螺杆菌感染胃黏膜组织的 DNA 及 RNA氧化损伤水平比较及致癌机制探讨
Clinical significance of DNA and RNA oxidative damage in human gastric mucosa infected with helicobacter py-lori
摘要
Abstract
Objective By comparing the amount of DNA and RNA oxidative damage detected in human gastric mucosa of helicobacter pylori infected individuals with that of a matched population control.To explore the effects of oxi-dation in Hp related gastric cancer.Methods The gastric mucosa of 60 patients,30 of patients with and 30 of patients without Helicobacter pylori,were collected and examined via immunohistochemistry.DNA and RNA oxidative damage were detected and analyzed.Results The level of RNA oxidation was significantly higher in patients with Hp(OD =0. 117 ±0.015)than the controls(OD =0.073 ±0.012)(P <0.05).DNA oxidation was higher in the Hp group as well, but without statistical significance(P >0.05).Conclusion The increased level of RNA oxidation in Hp infected indi-viduals may be involved in the underlying mechanism of Hp related gastric cancer.关键词
胃肿瘤/幽门螺杆菌/免疫组织化学/氧化性应激Key words
Stomach neoplasms/Helicobacter pylori/Immunohistochemistry/Oxidative stress分类
医药卫生引用本文复制引用
刘晓,罗庆峰,王振贺,蔡剑平,王化虹..幽门螺杆菌感染胃黏膜组织的 DNA 及 RNA氧化损伤水平比较及致癌机制探讨[J].中国临床保健杂志,2016,19(2):138-140,225,4.基金项目
国家人力资源和社会保障部资助课题 （）
