农药学学报2016，Vol.18Issue(2)：249-257,9.DOI:10.16801/j.issn.1008-7303.2016.0033
均匀设计和响应面法联用优化30%噻虫胺悬浮剂配方
Formula optimization of clothianidin 300SC based on the combination of uniform design and response surface method
摘要
Abstract
The formula of clothianidin 300SC was optimized by combining the uniform design and the response surface method. Partial least squares quadratic polynomial and stepwise regression quadratic polynomial model were used to analyze the results about the effect of the wetting-suspending agent and the viscosity modifier on the thermal stability. It was indicated that both the two models were capable of predicting the aqueous separation rate after hot storage (ASRHS) with theR2 of 0.941 1 and 0.999 9, respectively. The two formulas proposed by predicting models for ASRHS were both favorable formulas, of which the ASRHS were lower than 5% and the suspensibilities before and after the hot storage were higher than 92%. Besides, stepwise regression quadratic polynomial model was the better one, along with the average relative errors of predicted values of –4.85%. The optimal conditions were adding T2700, NR1602, xanthan gum and veegum at mass fraction of 3%, 0.4%, 0.22% and 2%. Under the optimal conditions the minimum value of ASRHS was 2.27% ± 0.08% and the suspensibility before and after hot storage were 92.51% ± 0.25% and 92.02% ± 0.46%. Furthermore, favorable dispersibility and flowability were observed under those conditions. Fortunately, no flocculation, agglomerate or knot at the bottom was observed even after hot storage. The ASRHS of samples remained lower than 5% and other performance was also qualified even when the dosage of T2700 was appropriately reduced according to the response surface results. The combination of uniform design and response surface method demonstrated favorable adaptability in the optimization of SC formula.关键词
均匀设计/响应面法/偏最小二乘/逐步回归/噻虫胺/悬浮剂/物理稳定性Key words
uniform design/response surface method/partial least squares/stepwise regression/clothianidin/suspension concentrate/physical stability分类
化学化工引用本文复制引用
王伟昌,张宪鹏,张大侠,李北兴,刘峰..均匀设计和响应面法联用优化30%噻虫胺悬浮剂配方[J].农药学学报,2016,18(2):249-257,9.基金项目
国家公益性行业(农业)科研专项(201303027)；国家自然科学基金项目(31572040) （农业）
