山东医药2016，Vol.56Issue(11)：11-13,3.DOI:10.3969/j.issn.1002-266X.2016.11.004
非小细胞肺癌组织中p-mTOR、p70 s6 k的表达变化及其临床意义
Expression of p-mTOR and p70s6k in non-small-cell lung cancer and its clinical significance
摘要
Abstract
Objective To observe the expression changes of phosphorylated mammalian target of rapamycin (p-mTOR) and p70s6k protein in non-small-cell lung cancer (NSCLC) tissues and to discuss its clinical significance .Meth-ods Eighty-two cases of patients with NSCLC were selected .The tumor tissues obtained from surgery (lung cancer group) , 46 cases of tissue samples from alveolus healthy tissues (control group 1) , and 50 cases of tissue samples from bronchus mucosal tissues (control group 2) were collected.The expression of p-mTOR and p70s6k protein in the three groups was measured by immunohistochemistry and we analyzed the relationships with the clinical and pathological data . Results The positive expression rates of p-mTOR protein in the lung cancer group , control group 1 and control group 2 were 68.29%, 17.39% and 32.0%, respectively.The positive expression rates of p70s6k protein in the lung cancer group, control group 1 and control group 2 were 85.37%, 21.74%and 32.00%, respectively.Significant difference was found between the lung cancer group and the control group 1, control group 2 (all P＜0.01).The expression of p-mTOR protein in poorly differentiated cancer tissues was significantly higher than that of medium and high differentiation cancer tis -sues (P＜0.01).In the NSCLC tissues, the p-mTOR and p70s6k expression was positively correlated (r=0.210, P=0.0032).Conclusion p-mTOR and p70s6k protein is highly expressed in NSCLC tissues , which may be used as the early-warning index in the early diagnosis or as a new target for anti-cancer drug.关键词
肺肿瘤/非小细胞肺癌/磷酸化雷帕霉素靶蛋白/核糖体40s小亚基S6蛋白激酶Key words
lung neoplasms/non-small-cell lung cancer/phosphorylated mammalian target of rapamycin/p70s6k分类
医药卫生引用本文复制引用
许浩然,吕艳超,韩双双,王丽红,岳洪娟,王嘉..非小细胞肺癌组织中p-mTOR、p70 s6 k的表达变化及其临床意义[J].山东医药,2016,56(11):11-13,3.基金项目
河北省医学科学研究重点课题计划项目(20090333) （20090333）
河北省科技计划自筹经费项目(152777233). （152777233）
