山东医药2016，Vol.56Issue(12)：5-8,4.DOI:10.3969/j.issn.1002-266X.2016.12.002
肝移植患者术后14天内胆汁中胆汁酸水平变化及其对缺血性胆管损伤发生的预测价值
Bile acid level in the bile of patients within 14 days after liver transplantation and its predictive value for occurrence of ischemic-type biliary lesions
摘要
Abstract
Objective To detect the levels of bile acids in the bile of patients within 14 days after liver transplantation and to investigate their predictive value for the occurrence of ischemic-type biliary lesion ( ITBL) .Methods Thirty-nine orthotopic liver transplant patients were selected.Using LC-MSMS to detect the contents of six kinds of bile acids including glycocholic acid ( GCA) , taurocholic acid ( TCA) , TLCA, glycochenodeoxycholic acid ( GCDCA) , glycine combined with deoxycholic acid (GDCA) and taurine combined with deoxycholic acid(TDCA) on day 1, 3, 7 and 14.They were followed up for three months after surgery, and then we determined whether ITBL occurred according to cholangiography results which served as gold standard, and compared the content of each bile acid on day 1, 3, 7 and 14 between patients with IT-BL ( ITBL group) and patients without ITBL ( N-ITBL group) .We used ROC curve to assess the predictive value of bile acids for the occurrence of ITBL.Results On day 1, the content of GDCA was lower in the ITBL group than that in the N-ITBL group;on day 7, the contents of GCA and GDCA were higher in the ITBL group than those in the N-ITBL group;on day 14, the contents of TLCA, GCDCA and GDCA were higher in the ITBL group than those in the N-ITBL group, and sig-nificant difference was found between these two groups (all P＜0.05).Analysis results of ROC carve showed that the AUC of GCDCA on day 14 for the occurrence of ITBL was 0.751, AUC of GCA on day 7 was 0.717, and AUC of TLCA on day 14 was 0.764.Conclusion The contents of GCDCA, GCA and TLCA within 14 days after liver transplantation are in-creased and they all can be used as reliable indexes to predict whether ITBL occurs within 3 months after surgery.关键词
肝脏移植/胆汁酸/缺血性胆管损伤Key words
liver transplantation/bile acid/ischemic-type biliary lesions分类
医药卫生引用本文复制引用
孙晓叶,康永振,沈中阳..肝移植患者术后14天内胆汁中胆汁酸水平变化及其对缺血性胆管损伤发生的预测价值[J].山东医药,2016,56(12):5-8,4.基金项目
国家高技术研究发展计划(2012AA021001) （2012AA021001）
国家临床重点专科建设项目(201354408) （201354408）
天津市卫生局攻关项目(12KG103). （12KG103）
