山东医药2016，Vol.56Issue(12)：20-23,4.DOI:10.3969/j.issn.1002-266X.2016.12.006
非小细胞肺癌组织中DEC1 mRNA、DEC2 mRNA表达及意义
Expression and clinical significance of DEC1/DEC2 mRNA in non-small-cell lung cancer
摘要
Abstract
Objective To investigate the effects of differentiated embryo-chondrocyte expressed gene 1 (DEC1) and DEC2 mRNA in the occurrence and development of non-small-cell lung cancer (NSCLC).Methods Forty-two cases of cancer tissue samples and 28 cases of adjacent normal tissues were collected from NSCLC patients.The relative expression levels of DEC1 and DEC2 mRNA were detected by real-time RT-PCR.The relationships between DEC1 and DEC2 mRNA and the clinicopathological characters of NSCLC patients were discussed.Results The relative expression of DEC1 mRNA was 0.0456 in the cancer tissues and 0.0017 in the normal tissues, the relative expression of DEC2 mRNA in the cancer tissues and normal tissues was respectively 0.0566 and 0.0009, and significant difference was found between these two groups ( all P＜0.05) .The expression of DEC1 and DEC2 mRNA in the NSCLC tissues was not related with gender, age, tumor diameter, differentiated degree and TNM stage (all P＞0.05).DEC1 and DEC2 mRNA was expressed higher in the adenocarcinoma than that in squamous carcinoma (all P＜0.05).DEC1 mRNA was positively correlated with DEC2 mR-NA (γ=0.691, P＜0.05).Conclusion DEC1 and DEC2 is over expressed in NSCLC tissues and its expression changes may be involved in the occurrence and development of NSCLC.关键词
非小细胞肺癌/分化型胚胎软骨发育基因1/分化型胚胎软骨发育基因2/相对定量实时RT-PCRKey words
non-small-cell lung cancer/differentiated embryo-chondrocyte expressed gene 1/differentiated embryo-chondrocyte expressed gene 2/relative quantitative real-time RT-PCR分类
医药卫生引用本文复制引用
马育华,彭海英,王志蕙,高伟,汪运山..非小细胞肺癌组织中DEC1 mRNA、DEC2 mRNA表达及意义[J].山东医药,2016,56(12):20-23,4.基金项目
临沂市科技发展计划项目(201313002). （201313002）
