摘要
Abstract
Objective:To explore the effect of tiotropium bromide combined with symbieort turbuhaler on respiratory function and exercise tolerance in elderly patients with severe COPD.Methods:A total of 106 patients with severe stable COPD were randomly divided into group A and group B,each group with 53 cases.Group A received inhalation of tiotropium bromide powder (18 μg,1/d) combined with symbicort turbuhaler (160/5.4 μg,2/d),and group B received inhalation of tiotropium bromide powder (18 μg,1/d) alone for 6 months.The pulmonary function,arterial blood gas,IL-8,IL-10 induced in sputum and exercise tolerance of all patients were assessed before and six months after the treatment.Results:Compared with before the treatment,levels of FEV1％ pred,FEV1/FVC,6MWD,PaO2 and IL-10 induced in sputum were significantly increased while PaCO2 and IL 8 induced in sputum were significantly decreased in two groups after the treatment.Improvements of all parameters were more obvious in group A than those in group B.Conclusion:The tiotropium bromide combined with symbicort turbuhaler was superior to any single-agent treatment in improving airway inflammation,respiratory function and exercise tolerance in elderly patients with severe stable COPD.关键词
慢性阻塞性肺疾病/呼吸功能/运动耐力/噻托溴铵/布地奈德/福莫特罗Key words
chronic obstructive pulmonary disease/respiratory function/exercise tolerance/tiotropium bromide/budesonide/formoterol分类
临床医学
