厦门大学学报（自然科学版）2016，Vol.55Issue(2)：178-183,6.DOI:10.6043/j.issn.0438-0479.2016.02.006
绿色化学方法合成儿茶酚-壳聚糖水凝胶的应用
A Green and Mix-to-use Approach for Mussel Inspired Chitasan-Catechol Hydrogel
摘要
Abstract
Hydrogels have important applications in biomedical fields,such as promoting wound healing.Herein we tried to develop chitosan based adhesive hydrogels as tissue adhesives.We developed a green and mix-to-use approach for generation of mussel in-spired chitasan-catechol hydrogel.An in situ gel-forming system composed of 2,4,5-three hydroxy benzaldehyde or 2,3,4-three hy-droxy benzaldehyde conj ugated chitosan derivatives was easily prepared,producing the hydrogels CC-1 and CC-2 respectively.In vitro study demonstrated that CC-1 could inhibit the growth of Staphylococcus aureus whereas CC-2 was a superior adhesive.In vivo wound healing study was performed by smearing hydrogels on rat dorsal wounds with a diameter of 10 mm and keeping them on for 14 days.Histological results demonstrated that CC-1 hydrogel was of high performance and comparable to commercialized wound dressing (DuoDERM)on wound healing.This approach is advantageous as no toxic byproducts are generated during making CC-1 and CC-2 hydrogels and only water is produced following formation of Schiff-base promoted hydrogels.The mix-to-use technique is of significance for commercial application.关键词
壳聚糖/儿茶酚/水凝胶/生物黏附Key words
chitosan/catechol/hydrogel/bioadhesive分类
化学化工引用本文复制引用
陈曦,俞明珠,刘剑,杨柳,韩守法..绿色化学方法合成儿茶酚-壳聚糖水凝胶的应用[J].厦门大学学报（自然科学版）,2016,55(2):178-183,6.基金项目
国家自然科学基金(21305116) （21305116）
高等学校博士学科点专项科研基金(20130121120003) （20130121120003）
福建省自然科学基金(2014J01059,2011J06004) （2014J01059,2011J06004）
湖南大学化学生物传感与计量学国家重点实验室基金(2012002) （2012002）
