中国当代儿科杂志2016，Vol.18Issue(4)：292-296,5.DOI:10.7499/j.issn.1008-8830.2016.04.002
原血细胞对于儿童急性B淋巴细胞白血病预后判断的价值
Prognostic value of bone marrowhematogones in childhood B-lineage acute lymphoblastic leukemia
摘要
Abstract
ObjectiveTo study the prognostic value of hematogones (HGs) for childhood B-lineage acute lymphoblastic leukemia (B-ALL) during consolidation chemotherapy.MethodsA retrospective analysis was conducted for 196 children with newly-diagnosed B-ALL. They were divided into high-risk group (n=55), intermediate-risk group (n=69), and low-risk group (n=72) by risk stratiifcation, and into complete remission group (n=165) and relapse group (n=31) by clinical outcome. The European BIOMED-1 standard lfow cytometry for minimal residual disease (MRD) was used to determine the number of HGs during consolidation chemotherapy. The Kaplan-Meier survival curve was used to assess event-free survival (EFS).ResultsThe high-risk group had a signiifcantly lower number of HGs than the intermediate-risk and low-risk groups (P<0.05). The number of HGs in the complete remission group was signiifcantly higher than in the relapse group (P<0.05). The children with HGs ≤1.0% had a signiifcantly lower EFS than those with HGs >1.0% (P<0.05).ConclusionsHGs can be used to assess the treatment outcome and prognosis in children with B-ALL, and proliferation of HGs relfects the good effect of chemotherapy in such children.关键词
急性B淋巴细胞白血病/流式细胞术/原血细胞/微小残留病/儿童Key words
B-lineage acute lymphoblastic leukemia/Flow cytometry/Hematogone/Minimal residual disease/Child引用本文复制引用
王月芳,江咏梅,高举,周平,张鸽..原血细胞对于儿童急性B淋巴细胞白血病预后判断的价值[J].中国当代儿科杂志,2016,18(4):292-296,5.基金项目
由四川省科技厅基金项目资助，四川省应用基础研究计划项目（2015JY0044）。 （）
