中国康复理论与实践2016，Vol.22Issue(3)：278-281,4.DOI:10.3969/j.issn.1006-9771.2016.03.008
甘丙肽2型受体激动剂对慢性温和应激模型大鼠抑郁样行为的影响
Effects of Galanin Receptor 2 Agonist on Depression-like Behavior in Chronic Mild Stress Model Rats
摘要
Abstract
Objective To explore the effect of intracerebroventricular injection of AR-M1896, a galanin receptor 2 agonist, on depres-sion-like behavior in rat chronic mild stress (CMS) model. Methods 48 Sprague-Dawley rats were randomly assigned into control group, CMS group, CMS artificial cerebrospinal fluid (aCSF) group and CMS AR-M1896 group equally. The control group received no interven-tion, and the other groups were established chronic mild stress model. After six-week of stress, forced swim test and sucrose preference test were conducted to identify the CMS rats. AR-M1896 or aCSF was injected into the lateral ventricle of CMS AR-M1896 group and CMS aC-SF group, respectively. The immobility time and climbing time in the forced swim test were analysed, and the sucrose consumption percent-age in the sucrose preference test was measured. Results The immobility time decreased (F=11.998, P<0.01), climbing time increased (F=8.268, P<0.05), and the sucrose consumption percentage increased (F=10.352, P<0.01) in CMS AR-M1896 group, compared with CMS aC-SF group. Conclusion Intracerebroventricular administration of galanin receptor 2 agonist AR-M1896 is effective on depression in CMS model rats.关键词
慢性温和应激/抑郁/甘丙肽2型受体激动剂/大鼠Key words
chronic mild stress/depression/galanin receptor 2 agonist/rats分类
医药卫生引用本文复制引用
张攀,刘博,王彤,李慧,杨予涛,徐志卿..甘丙肽2型受体激动剂对慢性温和应激模型大鼠抑郁样行为的影响[J].中国康复理论与实践,2016,22(3):278-281,4.基金项目
国家自然科学基金面上项目(No.31171032). （No.31171032）
