中国康复理论与实践2016，Vol.22Issue(3)：293-298,6.DOI:10.3969/j.issn.1006-9771.2016.03.012
脊髓损伤后神经再生相关信号通路研究进展
Nerve Regeneration Related Signaling Pathway after Spinal Cord Injury (review)
摘要
Abstract
As the nerve regeneration has been researched more and more, nerve regeneration related signaling pathways after spinal cord injury (SCI) comes into the view. Inhibiting apoptosis signaling pathways may reduce the apoptosis, inflammation and nerve degenera-tion after SCI. Mitogen activated protein kinase (MAPK) signaling pathway plays an important role in regulation of gene expression, cell proliferation and apoptosis, and there was interaction among the four subordinate pathways. Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway does not only participate in the body cell survival, proliferation, differentiation and apoptosis, but also in the process of inflammatory and oxidative stress in the body. It has been found that blocking the Wnt signaling pathway after inju-ry in the central nervous system would inhibit neural axon regeneration. Exogenous Wnt3a can increase the number of neurons after SCI and promote the axon conduction and nerve function. Inhibiting mammalian target of rapamycin (mTOR) signaling pathway after SCI can signif-icantly reduce neuronal loss, cell death and well promote the functional recovery. When Notch signaling pathways are activated, neural stem cells proliferate actively and differentiation are inhibited, and stem cells enter the stage of differentiation as the pathway inhibited. Activa-tion of Ras homolog gene/Rho associated coiled coil forming protein kinase (Rho/ROCK) signaling pathways leads to the collapse of the growth cone, inhibition of axon regeneration, whereas the selective inhibition of Rho can promote axon regeneration and recovery of motor function after SCI.关键词
脊髓损伤/神经再生/信号通路/机制/综述Key words
spinal cord injury/nerve regeneration/signaling pathways/mechanism/review分类
医药卫生引用本文复制引用
吕威,姚海江,莫雨平,李冰,景泉凯,宋良玉,王鑫,李志刚,时素华..脊髓损伤后神经再生相关信号通路研究进展[J].中国康复理论与实践,2016,22(3):293-298,6.基金项目
国家自然科学基金项目(No.81373728). （No.81373728）
