中国内镜杂志2016，Vol.22Issue(3)：23-28,6.DOI:10.3969/j.issn.1007-1989.2016.03.005
吲哚美辛栓预防高危人群发生内镜逆行胰胆管造影术后胰腺炎给药时机的前瞻性研究
Timing of Indomethacin suppositories for the prevention of post-ERCP pancreatitis in high risk groups
刘云燕 1丁百静 1陈明锴 2曹中保 1李生 1杨勇 1刘充 1程珍1
作者信息
- 1. 皖南医学院附属芜湖市第二人民医院 消化内科,安徽 芜湖 241000
- 2. 武汉大学人民医院 消化内科,湖北 武汉 430060
- 折叠
摘要
Abstract
Objective A prospective randomized controlled trial was carried out to explore the best time of In-domethacin suppositories administration for the prevention of post-ERCP pancreatitis in high-risk groups. Methods 81 patients were enrolled in the study finally. Patients were randomized into group A (100 mg rectal Indomethacin suppositories was administrated immediately after ERCP), group B (100 mg rectal Indomethacin suppositories was administrated half an hour after ERCP) and group C (ERCP alone group, which did not give Indomethacin supposito-ries). The level of serum amylase, urine amylase, serum CRP, serum IL-6, serum TNF-α were measured before, 3 h, 24 h and 48 h after ERCP, and the incidence of PEP and hyperamylasemia were analyzed. Results There was 1 case (4.00%) of PEP in group A, 2 cases (5.41%) of PEP in group B and 5 cases (26.31%) of PEP in group C;the incidences of PEP of group A and group B were significant lower than that in group C (P < 0.05). There was 1 case (4.00%) of hyperamylasemia in group A, 5 cases (13.51 %) of hyperamylasemia in group B and 6 cases (31.6 %) of hyperamylasemia in group C, and the incidences of hyperamylasemia of group A and group B were significant lower than that in group C ( P< 0.05). Conclusion Administration of 100 mg Indomethacin suppositories immediately or half an hour after ERCP can effectively reduce the incidence of PEP and hyperamylasemia.关键词
内镜逆行胰胆管造影/术后胰腺炎/C反应蛋白/白细胞介素6/肿瘤坏死因子αKey words
endoscopic retrograde cholangiopancreatography/post-ERCP pancreatitis/C reactive protein/inter-leukin 6/tumor necrosis factor-α分类
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刘云燕,丁百静,陈明锴,曹中保,李生,杨勇,刘充,程珍..吲哚美辛栓预防高危人群发生内镜逆行胰胆管造影术后胰腺炎给药时机的前瞻性研究[J].中国内镜杂志,2016,22(3):23-28,6.
