摘要
Abstract
Objective To study the effect of different fluids on early fluid resuscitation for brain natriuretic peptide (BNP) and prognosis in patients with septic shock, as a reference for clinical treatment. Method 82 patients with septic shock were randomly divided into four groups according to the fluids used in resuscitation: physiological saline resuscitation group (group A), 4% hypertonic saline resuscitation group (group B), hydroxyethyl starch resuscitation group (group C) and hypertonic sodium chloride hydroxyethyl starch 40 injection group (group D). EGDT standard rate, mortality, change of plasma BNP and APACHE Ⅱscores were compared among the four groups. Result There was no significant difference in the standard rate of EGDT and recovery rate among the four groups in 6 hours after resuscitation (P > 0.05). Ringer-locke liquor of group A was the most, but there was no significant difference compared with the other three groups (P > 0.05). There was significant difference in the study liquid and total recovery liquid in A, B, C, D groups (P < 0.05). The level of BNP was decreased after resuscitation, 6 hours after recovery treatment, the levels of BNP in the four groups were significantly different among the four groups; 6 and 72 hours after recovery treatment, the differences among the four groups in the serum levels of BNP were statistically significant (P < 0.05). 72 hours after treatment, the APACHE Ⅱ scores of the four groups were declined, group C and group D were decreased significantly (P < 0.05). 72 hours after treatment, the APACHE Ⅱ scores of group D were lower than group A and group B (P < 0.05), and the 28 days fatality rate was lower than group A, B,C (P < 0.05). Conclusion Hydroxyethyl starch 40 injection can improve the hemodynamic, maintain lower total resuscitation volume, decrease serum BNP level and improve the prognosis of patients with septic shock.关键词
感染性休克/早期复苏/脑钠肽Key words
Septic shock/Early resuscitation/Brain natriuretic peptide
