摘要
Abstract
Objective To compare the clinical efficacy of gonadotropin-releasing hormone agonist (GnRH-a) and mifepristone in the treatment of uterine fibroids. Methods 86 cases of confirmed uterine fibroid patients according to clinical symptoms,gynecological ex-amination and B ultrasonic diagnosis were randomly divided into two groups,43 cases in each group. The GnRH-a group group A re-ceived GnRH-a subcutaneous injection in the anterior abdominal skin 3. 75 mg/time in 1-3 d of menstrual cramps,after that,the injection was repeated 1 time monthly,3. 75 mg/time for subcutaneous injection of 3 months;the mifepristone group group B took mifepristone 12. 5 mg/d orally for 3 months. The clinical efficacy and adverse reactions were compared between the two groups. Results The clinical symptoms of the two groups were improved significantly;the narrowing of fibroid volume by more than 20% in group A was 38 cases,accounting for 88. 37%,while in group B,the number was 41 cases,accounting for 95. 35%,which showed significant difference ( P < 0. 05). Conclusion Compared with GnRH-a,mifepristone treatment for uterine fibroids has better efficacy and is worthy of clin-ical promotion.关键词
子宫肌瘤/米非司酮/促性腺激素/疗效Key words
uterine fibroids/mifepristone/gonadotropin/efficacy分类
药学
