中国药业2016，Vol.25Issue(5)：7-11,5.
多奈哌齐治疗阿尔茨海默病的疗效相关基因多态性研究进展
Progress in Related Single Nucleotide Polymorphism in the Therapeutic Response of Donepezil in Patients with Alzheimer′s Disease
卢进 1万丽丽 2郭澄1
作者信息
- 1. 上海交通大学附属第六人民医院，上海 200233
- 2. 上海交通大学药学院，上海 200233
- 折叠
摘要
Abstract
Objective To summarize the progress in related single nucleotide polymorphism in the clinical efficacy of donepezil in pa-tients with Alzheimer's disease, to provide evidence to related study and clinical applications of donepezil. Methods Using databases such as PubMed and CNKI to analyze the genetic influencing factor and the clinical efficacy of donepezil for treating Alzheimer's dis-ease. Results and Conclusion The rate of clinical efficacy of patients to donepezil varies, most likely because of their genetic back-ground. The polymorphism of CYP2D6, CY3A4, APOE, ESR1, BCHE, PON-1, CHRNA7 and CHAT were closely related to the therapeutic response of donepezil in patient with Alzheimer's disease. They can be taken in consider to become the future biomarker in clinical therapy of donepezil.关键词
多奈哌齐/阿尔茨海默病/临床疗效/基因多态性/遗传标记物Key words
donepezil/Alzheimer's disease/clinical efficacy/single nucleotide polymorphism/genetic biomarker分类
药学引用本文复制引用
卢进,万丽丽,郭澄..多奈哌齐治疗阿尔茨海默病的疗效相关基因多态性研究进展[J].中国药业,2016,25(5):7-11,5.
