中国药业2016，Vol.25Issue(5)：12-15,4.
何首乌提取物对鱼藤酮所致帕金森病线虫模型的神经保护作用
Neuroprotective Effect of the Extract of P. multiflorum Thunb. in a Caenorhabditis elegans Model on Rotenone-Induced Parkinson′s Disease
摘要
Abstract
Objective To study the neuroprotective effect of polygonum extract on rotenone-induced Parkinson ’ s disease model nema-tode. Methods The experienment set control group, rotenone group and treatment group ( 0. 5 g/L, 1. 0 g/L ) , and their effect on nema-todes dopamine neurons dendrites, and oxygen levels influence survival in vivo activity were observed. Results Compared with the con-trol group, the 0. 5 g/L, 1. 0 g/L Polygonum extract on Parkinson disease model significantly inhibited dopamine phenotype of dendrit-ic, showed a significant increase in dopamine neuron dendrites normal proportion of nematodes, the reactive oxygen species was signifi-cantly lower than the rotenone group, and the nematode survival rate was significantly higher than rotenone group. Conclusion Polygon-um extract improves the nematode survival, inhibits rotenone-induced dopaminergic phenotype of dendritic. Polygonum extract has neuro-protective effects on rotenone-induced Parkinson ’ s disease, and its mechanism of inhibition is related to active oxygen production.关键词
帕金森病/何首乌/神经毒素/神经保护/秀丽隐杆线虫Key words
Parkinson's disease/P. multiflorum Thunb./neurotoxins/neuroprotection/Caenorhabditis elegans分类
医药卫生引用本文复制引用
李玉娟,段昌令,李连达,王丹巧..何首乌提取物对鱼藤酮所致帕金森病线虫模型的神经保护作用[J].中国药业,2016,25(5):12-15,4.基金项目
国家自然科学基金项目，项目编号81274121；中国中医科学院自主选题研究项目课题，项目编号ZZ2015003。 （）
