中国药业2016，Vol.25Issue(5)：21-23,24,4.
血管紧张素转化酶插入／缺失基因多态性与妊娠期高血压发病风险的Meta分析
Meta analysis about ACE Polymorphisms and Hypertensive Disorder Complicating Pregnancy
蒋艳 1王佳 1吴彦 1吴彦丽1
作者信息
- 1. 重庆医科大学附属大学城医院，重庆 401331
- 折叠
摘要
Abstract
Objective To analyze the association between Angiotensin Converting Enzyme ( ACE ) Insert/Deletion ( I/D ) gene and Hyper-tensive Disorder Complicating Pregnancy ( HDCP ) by meta-analysis, and to guide clinical therapy. Methods Case-control studies were searched in PubMed, CNKI, CBM et al. RevMan 5. 3 software was used for meta-analysis. Results Finally 20 literatures including 1 719 HDCP patients and 1 928 controls were eligible to the criteria. The results showed:Significant differences were found in the fre-quencies distribution of ACE DD genotype ( P=0. 004, OR=1. 60 [ 1. 17, 2. 21 ] ) and D allele ( P ﹤ 0. 000 01, OR=1. 68 [ 1. 36, 2. 08 ] ) . Conclusion Women carrying ACE DD, or ACE D gene would increase the risk of developing HDCP, which can be of clinical significance.关键词
血管紧张素转化酶/妊娠期高血压疾病/基因多态性/Meta分析Key words
angiotensin converting enzyme/hypertensive disorder complicating pregnancy/gene polymorphisms/meta analysis分类
医药卫生引用本文复制引用
蒋艳,王佳,吴彦,吴彦丽..血管紧张素转化酶插入／缺失基因多态性与妊娠期高血压发病风险的Meta分析[J].中国药业,2016,25(5):21-23,24,4.
