中国药业2016，Vol.25Issue(5)：24-26,3.
乳腺癌患者新辅助化学治疗后ERCC1基因表达情况研究
Expression of ERCC1 Gene in Breast Cancer after Neoadjuvant Chemotherapy
摘要
Abstract
Objective To study the expression of ERCC1 gene in breast cancer after neoadjuvant chemotherapy. Methods The expres-sion of ERCC1 gene was detected by RT-PCR in 28 breast cancer patients without neoadjuvant chemotherapy and in 18 breast cancer patients treated with neoadjuvant chemotherapy. The expression and clinicopathological features of breast cancer as well as the relevance of the impact of neoadjuvant chemotherapy on it were analyzed. Results No chemotherapy patients ERCC1 expression level was signifi-cantly lower than the normal group, the difference was statistically significant ( P ﹤ 0. 05 ) . The differences of ERCC1 gene expression levels of the non chemotherapy group between different ages, tumor sizes, histological types, histological grades, axillary lymph nodes, PR, ER, HER-2 were not significant ( P ﹥ 0. 05 ) . Neoadjuvant chemotherapy group ERCC1 gene expression levels were significantly higher than those without chemotherapy group, the difference was statistically significant ( P ﹤ 0. 05 ) . Conclusion Compared with the normal, ERCC1 gene expression levels were significantly decreased in patients with breast cancer ( P ﹤ 0. 05 ) and ERCC1 gene expression and Clinical pathological characteristics of breast cancer not associated, after neo-adjuvant chemotherapy in patients with raised the ERCC1 gene expression can occur, chemotherapy in the treatment of breast cancer patients have some reference value.关键词
ERCC1基因/乳腺癌/新辅助化疗Key words
ERCC1 gene/breast neoplasms/neoadjuvant chemotherapy分类
医药卫生引用本文复制引用
郑锐年,林顺欢,关灵,林钦雄,刘淳,卢志斌,吴少敏..乳腺癌患者新辅助化学治疗后ERCC1基因表达情况研究[J].中国药业,2016,25(5):24-26,3.基金项目
广东省东莞市科技计划项目，项目编号2015105101180。 （）
