中国药业2016，Vol.25Issue(6)：35-36,37,3.
恩替卡韦与拉米夫定抗病毒治疗重型乙型肝炎临床对照研究
Comparison of Entecavir and Lamivudine Antiviral Therapy in Treating Severe Hepatitis B
李虹庆 1赵具也 1罗刚 1陈薪屹1
作者信息
- 1. 四川省攀枝花市中心医院，四川 攀枝花 617067
- 折叠
摘要
Abstract
Objective To investigate the influence of entecavir for inflammatory and vascular endothelium cytokines with severe hepatitis B. Methods 80 cases were divided into two groups,40 cases in each group. The observation group used antiviral therapy with entecavir, and the control group used lamivudine. The TNF-α,IL-6 and VEGF levels before and after treatment and vascular permeability changes after 1 month were compared. Results After treatment,the TNF-α and IL-6 levels in the observation group were lower than before treatment( P ﹤ 0. 05),and were lower than control group after treatment( P ﹤ 0. 05);VEGF level in the observation group were lower than before treatment and the control group after treatment( P ﹤ 0. 05);the presence of ascites,portal hypertension and hypoalbu-minemia in the observation group were less than control group( P ﹤ 0. 05). Conclusion Eentecavir for inflammatory and vascular en-dothelium cytokines with severe hepatitis B can effectively inhibit the replication of hepatitis B virus and reduce the liver cell inflam-mation,can improve endothelial cell function,especially for hypoalbuminemia,ascites and portal hypertension.关键词
恩替卡韦/重型乙型肝炎/炎症因子/血管内皮功能Key words
entecavir/severe hepatitis B/inflammatory cytokines/vascular endothelial function分类
药学引用本文复制引用
李虹庆,赵具也,罗刚,陈薪屹..恩替卡韦与拉米夫定抗病毒治疗重型乙型肝炎临床对照研究[J].中国药业,2016,25(6):35-36,37,3.
