中国医院用药评价与分析2016，Vol.16Issue(3)：357-359,3.DOI:10.14009/j.issn.1672-2124.2016.03.029
枸杞多糖的提取及其抗衰老的研究
Research on the Extraction and Anti-aging of Lycium Barbarum Polysaccharide
刘杰 1潘晓秋 1周晖 1张海林 1齐宏亮 1廖丹 1倪雪松1
作者信息
- 1. 中国医科大学附属第一医院鞍山医院药学部，辽宁鞍山 114011
- 折叠
摘要
Abstract
OBJECTIVE:To optimize the optimum extraction technology of lycium barbarum polysaccharide and establish senile mice model by D-galactose , so as to research the anti-aging effects of lycium barbarum polysaccharide . METHODS:Orthogonal design method was adopted to research the extraction technology .The senile mice model was established by injection of D-galactose .The anti-aging capacibility of lycium barbarum polysaccharide were determined by the detection of malonaldehyde (MDA), glutathione peroxidase (GSH-PX), the content of catalase (CAT), activity of superoxide dismutase (SOD) and level of SOD, MDA and hydroxyproline (Hyp) in the skin.RESULTS:The optimum extraction technology scheme by orthogonal design method were : the ratio of solid to liquid was 1∶30, 2 times of extraction, 90 min for once, the power was 100 kHz.Lycium barbarum polysaccharide could increase the level of SOD , CAT and GSH-px in rats , decrease MDA , improve the SOD activity , decrease MDA and increase the content of Hyp in the skin of mice .CONCLUSIONS:The extraction method established by this research is simple and feasible , with high extraction rate of lycium barbarum polysaccharide .Meanwhile , lycium barbarum polysaccharide has significant effects on the senile mice model induced by injection of D-galactose .关键词
枸杞多糖/提取/抗衰老/D-半乳糖Key words
Lycium barbarum polysaccharide/Extraction/Anti-aging/D-galactose分类
医药卫生引用本文复制引用
刘杰,潘晓秋,周晖,张海林,齐宏亮,廖丹,倪雪松..枸杞多糖的提取及其抗衰老的研究[J].中国医院用药评价与分析,2016,16(3):357-359,3.
