北华大学学报（自然科学版）2016，Vol.17Issue(2)：213-216,4.DOI:10.11713/j.issn.1009-4822.2016.02.015
肺癌患者放疗前后外周血淋巴细胞亚群变化研究
On the Changes of Peripheral Blood Lymphocyte Subsets in Patients with Lung Cancer before and after Radiotherapy
摘要
Abstract
Objective To explore the changes of peripheral blood lymphocyte subsets in patients with lung cancer before and after chemoradiotherapy.Methods Flow cytometry was used to detect blood T lymphocyte subsets,B lymphocytes and NK cells of 30 healthy people ( control group ) and 68 cases of patients with nasopharyngeal carcinoma( observation group) before and after chemoradiotherapy.Comparisons were made in the testing results between the patients with nasopharyngeal carcinoma and the healthy people before and after chemoradiotherapy.Results Compared with the control group, CD3+, CD4+, CD4+/CD8+, CD19+ significantly decreased(P<0.05).The proportion of CD8+ was significantly higher than that of the control group(P<0.05), while the CD56+ratio was higher than that of the control group without statistical significance.After radiotherapy, CD3+ decreased and CD56+ increased,but the differences were not statistically significant(P<0.05).CD4+ and CD4+/CD8+ were significantly lower than before,CD8+ and CD19+ were significantly higher than before,and all the differences were statistically significant ( P<0 .05 ) .Conclusion All the patients show abnormal immune function and low immune function.The detection results of T,B lymphocyte and NK cells in peripheral blood can be a certain reference to determine the immune function of the patients.关键词
肺癌/淋巴细胞亚群/流式细胞术Key words
lung cancer/lymphocyte subsets/flow cytometry分类
医药卫生引用本文复制引用
李海洋,赵振山..肺癌患者放疗前后外周血淋巴细胞亚群变化研究[J].北华大学学报（自然科学版）,2016,17(2):213-216,4.
