摘要
Abstract
Objective To compare efficacy of different doses of oxycodone during induction of general anesthesia and to determine the appropriate dosage.Methods Eighty ASAⅠorⅡpatients aged 20~60 years undergoing elective laparoscopic surgery of gynecology or general surgery under general anesthesia were divided into 4 groups ( n=20 each) according to the following oxycodone doses, 0.1 mg/kg(Ox1), 0.15 mg/kg(Ox2), 0.2 mg/kg(Ox3), and fentanyl do-ses 3 μg/kg( F) .Anesthesia was induced with oxycodone or fentanyl.After 5 minutes, intravenous midazolam 0.03 mg/kg was administered with target controlled infusion ( TCI) of propofol( initial concentration set to 2.5μg/mL) .Rocuroni-um 0.6 mg/kg was injected IV.TCI of propofol was titrated at 0.1μg/mL until the narcotrend index (NI) ≤60.Trache-al intubation was then performed by single-cavity laryngoscopy.Mechanical ventilation was set at tidal volume of 8~10 mL/kg, respiratory rate of 12~14/min, end-respiratory PetCO2 of 35~40 mmHg.SBP,DBP,MAP and NI were contin-uously monitored during anesthesia and recorded immediately before induction (T0,baseline), immediately before intuba-tion(T1), exposure of glottis(T2), immediately and 1, 2, 3, 4, 5, 10 min after intubation (T3~T9).Results Com-pared with Group F, HR, SBP and DBP in Groups Ox2 and Ox3 were similar at each time point from T1 ~T9 ( P>0.05).HR, SBP and DBP in Group Ox1 at T3 and T4 were higher than those in Groups Ox2, Ox3 and F (P<0.05). There was no significant difference in NI among all groups.There was obvious respiratory depression in Group Ox3 and Group F(P<0.05).Conclusion 1.Oxycodone combined with propofol for induction of anaesthesia has similar efficacy as fentanyl combined with propofol.2.Oxycodone at 0.15 mg/kg is the appropriate dose during induction of anesthesia in this setting.关键词
羟考酮/芬太尼/全麻诱导/气管插管/麻醉/脑电意识监测/靶控输注Key words
oxycodone/fentanyl/general anesthesia induction/tracheal intubation/narcotrend/TCI
