摘要
Abstract
Objective To explore the expression changes and significance of estrogen receptor ( ER) , progesterone receptor ( PR) , Ki-67 and human epidermal growth factor receptor-2 (Her-2) in patients with breast cancer before and after neoadjuvant chemotherapy.Methods Retrospective analysis was conducted on clinical data of 99 patients with breast cancer who treated by neoadjuvant chemotherapy.The recent curative effect was observed and the expressions of ER, PR, Ki-67 and Her-2 before and after neoadjuvant chemotherapy were detected with immunohistochemical method.The correlation among them before chemotherapy, the relationship between the expressions of them before neoadjuvant chemotherapy and curative effect as well as the influence of neoadjuvant chemotherapy on expressions were analyzed.Results The expression of ER before neoadjuvant chemotherapy was significantly positively related to PR ( r =0.731, P =0.000), while significantly negatively related to Ki-67 (r =-0.298, P =0.003).And the expression of PR before neoadjuvant chemotherapy was also significantly negatively related to Ki-67 (r=-0.265, P=0.014).There were 16 cases with pathologic complete response (PCR) after chemotherapy, and the PCR rate was 16.16%.The PCR rate in ER and PR negative expression patients was higher than that in patients with positive expression, and the difference was statistically significant (χ2 value was 12.038 and 10.834, respectively, both P<0.05).Before chemotherapy, the total effective rate between hormone receptor, Ki-67 and Her-2 positive/negative expression or overexpression/non overexpression had no statistical significance (χ2 value was 0.38, 0.17, 0.13 and 0.04, respectively, all P>0.05).The positive rate of Ki-67 after neoadjuvant chemotherapy in 83 cases decreased significantly, and it was statistically significant (χ2 =7.923, P<0.05).The positive rate of ER and PR and overexpressoin rate of Her-2 had no significant changes, and the differences were not statistically significant (χ2 value was 0.965, 1.364 and 0.392, respectively, all P >0.05).Conclusion The expression of Ki-67 increases in patients with breast cancer whose expressions of ER and PR are negative, which indicates that proliferation is strong.The neoadjuvant chemotherapy can cut down the expression of Ki-67 and reduce tumor proliferation activity.Patients whose expressions of ER and PR are negative are more sensitive to neoadjuvant chemotherapy.The expression changes of ER, PR and Ki-67 in breast cancer tissue can effectively predict the curative effect of neoadjuvant chemotherapy.关键词
乳腺癌/雌激素受体/孕激素受体/Ki-67抗原/人表皮生长因子受体-2Key words
breast cancer/estrogen receptor (ER)/progesterone receptor (PR)/Ki-67/human epidermal growth factor receptor-2 (Her-2)分类
医药卫生
