摘要
Abstract
Objective To explore the oxidative stress state, inflammatory state and immune state in patients with laparoscopic uterine fibroids resection or open resection of uterine fibroids.Methods Sixty cases of uterine fibroids were divided into two groups according to operation mode, control group (30 cases) treated with open resection of uterine fibroids and observation group (30 cases) treated with laparoscopic uterine fibroids resection.The oxidative stress state, inflammatory state and immune state of two groups were compared. Results After surgery MDA in both groups showed the change of rising first and then decrease, while SOD and GSH-Px showed the change of decline first and then rising.One day, 3d and 7d after surgery, the differences in the indicators of oxidative stress state between two groups were significant (tMDA value was 6.44, 6.81 and 7.61, tSOD value was 6.30, 7.82 and 6.83, TGSH-Px value was 7.72, 6.89 and 6.32, respectively, all P<0.05).Postoperative inflammatory state indexes of IL-1β, CRP and TNF-αincreased first and then declined in two groups, and those of the observation group at 1d, 3d and 7d after surgery were significantly lower than the control group ( tIL-1βvalue was 6.30, 6.64 and 7.95, tCRP value was 6.52, 7.77 and 6.6, tTNF-αvalue was 7.48, 6.65 and 6.67, respectively, all P<0.05).The immune status indexes of CD3 +, CD4 +and CD8 + of two groups after surgery showed decrease first and then rising, and they could returned to preoperative levels 7d after surgery.The indexes of the observation group were significantly higher than those of the control group at 1d and 3d after surgery ( tCD3+value was 6.86 and 7.54, tCD4+value was 7.45 and 6.60, tCD8+value was 7.36 and 6.69, respectively, all P<0.05).Conclusion Laparoscopic resection of uterine fibroids has milder influence on perioperative oxidative stress, inflammatory state and immune status, and all indexes can quickly restore to preoperative levels, which is beneficial to recovery of patients.关键词
腹腔镜/子宫肌瘤/氧化应激/炎性状态/免疫状态Key words
laparoscopic/uterine fibroids/oxidative stress state/inflammatory state/immune state分类
医药卫生
