军事医学2016，Vol.40Issue(3)：221-225,5.DOI:10.7644/j.issn.1674-9960.2016.03.014
人源性抗菌肽hGlyrichin中保守结构域肽段功能验证
Verification of conserved domain peptides derived from human antimicrobial peptide hGlyrichin
摘要
Abstract
Objective To verify the antibacterial activity of the conserved domain derived from the novel human antimicrobial peptide-hGlyrichin .Methods Bioinformative analysis was performed and two peptides derived from hGlyrichin were synthesized which contained the conserved domain .Results Analysis of antimicrobial activities showed that these two peptides exhibited strong antibacterial activity which was inversely proportional to the length of the peptide within an eligible range.Despite the effective inhibition and killing of bacteria , the synthetic peptide segments had no hemolytic effect on human red blood cells .Conclusion These results indicate that a conserved domain exists in hGlyrichin , and that the peptides which contain this domain have strong antibacterial activity but are not toxic to human somatic cells .关键词
内源性抗菌多肽类物质/抗菌肽/hGlyrichin/保守结构域/溶血Key words
cathelicidins/antimicrobial peptides/hGlyrichin/conserved domain/hemolysis分类
生物科学引用本文复制引用
沙继斌,赵光,张成岗..人源性抗菌肽hGlyrichin中保守结构域肽段功能验证[J].军事医学,2016,40(3):221-225,5.基金项目
山东省高等学校科技计划项目（ J13 LE04），山东省自然科学基金资助项目 （）
