军事医学2016,Vol.40Issue(3):256-260,5.DOI:10.7644/j.issn.1674-9960.2016.03.023
CDC42与癌症
The role of CDC42 in cancer
摘要
Abstract
Cell division cycle 42 (CDC42)is a member of Rho guanosine triphosphatase (GTPase) family,which plays an important role in cell proliferation , cell migration and cell transformation .The activity of CDC42 can be regulated by guanine nucleotide exchange factors (GEFs),GTPase activating proteins (GAPs) and guanine nucleotide-dissociation inhib-itors (GDIs).Recently,CDC42 has been reported as abnormally expressed in many human cancers ,suggesting that CDC42 performs complex functions in tumorigenesis .Therefore,this paper aims to shed light on the functions of CDC 42 in cancers in terms of the alteration of CDC42 activity,CDC42 regulators,as well as its effectors.关键词
CDC42/癌症/细胞恶性转化/肿瘤Key words
CDC42/cancer/cell transformation/neoplasms分类
生物科学引用本文复制引用
徐永茹,徐平,徐锋,李湘萍..CDC42与癌症[J].军事医学,2016,40(3):256-260,5.基金项目
国家重点基础研究发展计划(2011CB910600,2013CB911200);国家自然科学基金资助项目(31470809,31170780);北京市自然科学基金资助项目 ()