军事医学2016，Vol.40Issue(3)：261-264,4.DOI:10.7644/j.issn.1674-9960.2016.03.024
马尔堡病毒疫苗研究进展
Progress in vaccine development of Marburg virus
李拓 1刘珠果 1戴秋云1
作者信息
- 1. 军事医学科学院生物工程研究所，北京 100071
- 折叠
摘要
Abstract
Marburg virus (MARV) is a member of the Filoviridae family and belongs to a non-segmented, single-strand and negative-sense RNA virus.Since the first discovery of virus in 1967, infections have broken out 14 times, causing the infection of 588 people and 482 deaths.The mortality is up to 82%.Marburg virus results in multiple organ infections , severe hemorrhagic fever and death .Currently, there are no available licensed vaccines or post-exposure treatment , but the vaccines have proved effective in experimental animals .This review briefly summarizes the structure , infection mechanism and the progress in vaccines of this virus .关键词
马尔堡病毒/感染机制/疫苗/中和抗体Key words
Marburg virus/infection mechanism/vaccines/neutralizing antibody分类
医药卫生引用本文复制引用
李拓,刘珠果,戴秋云..马尔堡病毒疫苗研究进展[J].军事医学,2016,40(3):261-264,4.
