检验医学与临床2016，Vol.13Issue(7)：868-869,872,3.DOI:10.3969/j.issn.1672-9455.2016.07.002
D-二聚体检测在进展性脑梗死中的临床价值
Clinical value of D-dimer assay in progressive cerebral infarction
摘要
Abstract
Objective To investigate the change and clinical application value of plasma D‐dimer in progressive cerebral infarction .Methods The plasma level of D‐dimer was measured and compared in 47 patients with progres‐sive cerebral infarction and 162 patients with non‐progressive cerebral infarction .The diagnostic performance of D‐di‐mer for progressive cerebral infarction was assessed by ROC cure .Results Among many monitoring indicators in the patients with cerebral infarction ,the plasma level of D‐dimer in the patients with progressing cerebral infarction was significantly higher than that in the patients with non‐progressive cerebral infarction (P<0 .01);the difference of D‐dimer level at different time periods of 0 ,24 ,48 ,72 h had statistical differences between two groups (P<0 .01) .The area under ROC curve of D‐dimer for progressing cerebral infarction diagnosis was 0 .859(95% CI:0 .745~0 .973) . When the cut off value was 1 510 μg/L ,the sensitivity and specificity for diagnosing progressive cerebral infarction were 95 .2% and 65 .7% respectively .Conclusion The plasma level of D‐dimer has an important clinical value for the auxiliary diagnosis of progressive cerebral infarction .关键词
D-二聚体/进展性脑梗死/诊断/灵敏度/特异性Key words
D-dimer/progressive cerebral infarction/diagnosis/sensitivity/specificity引用本文复制引用
高玉芳,赵联营,王敏,罗文强,张建平,田亚平..D-二聚体检测在进展性脑梗死中的临床价值[J].检验医学与临床,2016,13(7):868-869,872,3.基金项目
国家863计划课题资助项目（2011AA02A111）。 （）
