检验医学与临床2016，Vol.13Issue(7)：920-922,3.DOI:10.3969/j.issn.1672-9455.2016.07.022
昆明市2009～2013年 B 型流感病毒血凝素及耐药基因分析
Analysis on hemagglutinin and drug resistance gene of influenza B virus in Kunming City during 2009-2013
曹亿会 1李娟 1蒋立 1赵晓南 1宁德明 1罗春蕊 1徐闻1
作者信息
- 1. 云南省疾病预防控制中心，昆明 650022
- 折叠
摘要
Abstract
Objective To study the HA and NA complete genome sequence of influenza B virus to provide support for controlling influenza .Methods The representative strains isolated from the enfluenza laboratory of our center were performed the HA and NA complete genome sequence analysis .Results Compared with the standard strain ,the K129N ,K80R ,K48E mutation were found in the Bv type virulent strains ,in which K129N was in 120 ring area ,except isolated strains in 2009 ,other Bv strains all had 75 locus mutation .The HA gene in By virulent strain had many same mutation loci ,such as N116K ,S150I ,N165Y ,S229D and D196N .The isolated strains in Yunnan all had D196N mutation locus ,which increasing the possibility of glycosylation locus .The research found that all the NA genes had no drug‐resistance gene mutation ,the homology was relatively higher ,but the recombinant strains were generated .Conclusion The isolated strains of influenza B in Yunana have many mutation sites ,moreover the genera‐tion of recombinant strains is found ,indicating the importance for strengthening drug resistance monitoring .关键词
B型流感病毒/神经氨酸酶/血凝素/突变Key words
influenza B/neuraminidase/hemagglutinin/mutation引用本文复制引用
曹亿会,李娟,蒋立,赵晓南,宁德明,罗春蕊,徐闻..昆明市2009～2013年 B 型流感病毒血凝素及耐药基因分析[J].检验医学与临床,2016,13(7):920-922,3.
