临床口腔医学杂志2016，Vol.32Issue(3)：157-161,162,6.DOI:10.3969/j.issn.1003-1634.2016.03.009
以同种异体BMMSCs为基础构建组织工程骨修复种植区骨缺损的实验研究
Allogeneic BMMSCs-based tissue-engineering bone repairing bone defect in dental implant region:an experi-mental study
朱彪 1刘静 1赵刚 2焦婷 3郭希民 2郭红延1
作者信息
- 1. 武警总医院口腔医学中心 北京 100039
- 2. 军事医学科学院基础医学研究所 北京 100850
- 3. 河北大学附属医院肿瘤科 河北 保定 071000
- 折叠
摘要
Abstract
Objective:To study the osteogenesis potential of tissue- engineering bone with allogeneic bone marrow mesenchymal stem cells for repairing bone defect in dental implant region. Method:Bilateral premolars were extracted in 4 Beagles. 3 months later,2 implants were respectively implanted in each side of the mandible,and a bone defect was created in the distal of each implant. Allogeneic (n=8,the experimental group)and autologous (n=8,the control group)BMMSCs-based tissue-engineering bone were respectively applied into the defects. 1 and 3 months after transplation,gross investiga-tion and histological observation were made. The bone density at the grafting area was measured by topographic technic. Re-sult:Immediately after implantation,the bone density of allo-BMMSCs group and auto-BMMSCs was 81±9 and 79±9 (P>0.05),1 month after implantation 97±9 and 97±9 (P>0.05),3 months after implantation 115±12 and 112±11 (P>0.05). Conclusion:Allogeneic bone marrow mesenchymal stem cell-based tissue- engineered bone has high osteogenic potential around dental implants.关键词
骨髓间充质干细胞/同种异体/组织工程骨/口腔种植Key words
Bone marrow mesenchymal stem cells/Allogeneic/Tissue-engineered bones/Oral implantology分类
医药卫生引用本文复制引用
朱彪,刘静,赵刚,焦婷,郭希民,郭红延..以同种异体BMMSCs为基础构建组织工程骨修复种植区骨缺损的实验研究[J].临床口腔医学杂志,2016,32(3):157-161,162,6.
