临床神经外科杂志2016，Vol.13Issue(2)：118-121,126,5.DOI:10.3969/j.issn.1672-7770.2016.02.011
LRIG1、EGFR、E-Cadherin及N-Cadherin在胶质瘤中表达及其临床意义
Expression of LRIG1, EGFR, E-Cadherin and N-Cadherin in astrocytoma and their clinical significances
摘要
Abstract
Objective To observe the expression of Leucine-rich repeats and immunoglobulin-like domains protein 1(LRIG1),epidermal growth factor receptor(EGFR),E-Cadherin and N-Cadherin in astrocytoma and explore the possible mechanism of glioma progression.Methods 74 astrocytoma surgical specimens, including 12 pairs of primary and recurrent specimens were studied.LRIG1, EGFR, E-Cadherin, N-Cadherin gene and protein expression were detected by qRT-PCR and Western Blotting respectively.Results LRIG1 and E-Cadherin gene and protein expression were higher,while EGFR and N-Cadherin expression were lower in the more malignant glioma samples( all P<0.05 ) .The ratio of EGFR/LRIG1 and N-Cadherin/E-Cadherin in WHO Ⅲ-Ⅳ group was significantly higher than that in WHOⅠ-Ⅱgroup ( all P<0.05) .EGFR/LRIG1 and N-Cadherin/E-Cadherin were positively correlated(r =0.56,P <0.05).The study of primary and recurrent paired astrocytoma samples had similar findings as above.Conclusions Imbalance of EGFR/LRIG1 expression may promote glioma progression by inducing epithelial-mesenchymal transition of glioma cells.LRIG1 may become a new target for the treatment of glioma.关键词
LRIG1/表皮生长因子受体/脑胶质瘤/上皮间质转化Key words
LRIG1/epidermal growth factor receptor/glioma/epithelial-mesenchymal transi-tion分类
医药卫生引用本文复制引用
王鹏,杨勇,王景文,胡昌龙,袁志诚,陆培松,湛利平,李巧玉..LRIG1、EGFR、E-Cadherin及N-Cadherin在胶质瘤中表达及其临床意义[J].临床神经外科杂志,2016,13(2):118-121,126,5.基金项目
镇江市社会发展项目(SH2011035,SH2013050) （SH2011035,SH2013050）
江苏大学医学临床科技发展基金项目( JLY20140015 ) （ JLY20140015 ）
