临床神经外科杂志2016，Vol.13Issue(2)：127-130,4.DOI:10.3969/j.issn.1672-7770.2016.02.013
轻型颅脑损伤后患者血清生物标志物GFAP含量的临床研究
Research of serum glial fibrillary acidic protein in patients with mild traumatic brain injury
摘要
Abstract
Objective To provide basis for diagnosis the patients with mild traumatic brain injury ( mTBI) by detecting and comparing separately the contents of the serum glial fibrillary acidic protein( GFAP ) among patients with ( mTBI ) , the patients with moderate traumatic brain injury whose glasgow coma scale ( GCS ) score is 13 -15 points and healthy control group.Methods Detected serum GFAP content by ELISA in 43 cases of patients with mTBI, 35 cases of patients with moderate traumatic brain injury whose GCS score is 13 -15 points and 20 healthy subjects, then using ROC curve analysis the results.Results There is a certain accuracy ( AUC =0.726) that serum GFAP content may distinguish between the patients with mTBI and healthy people, high accuracy( AUC=0.914) in distinguish between the patients with patients with moderate traumatic brain injury and healthy people.It has a certain accuracy (AUC=0.762) that serum GFAP content can distinguish between patients with positive and negative head CT.Conclusion The content of serum GFAP can be used as a biomarker in diagnose the patients with mTBI.It has a certain accuracy that can distinguish between patients with positive and negative head CT, and can reduce the examination of head CT in patients with mTBI.关键词
轻型颅脑损伤/胶质细胞纤维酸性蛋白/头颅计算机体层成像Key words
GFAP/mTBI/head CT分类
医药卫生引用本文复制引用
葛岭,薛龙,尧荣凤,黄晓伟,陈洁波,许静,施君..轻型颅脑损伤后患者血清生物标志物GFAP含量的临床研究[J].临床神经外科杂志,2016,13(2):127-130,4.基金项目
同济大学附属杨浦医院院级科研基金项目( Se1201410) （ Se1201410）
