畜牧与饲料科学2016，Vol.37Issue(3)：7-10,4.
硫酸卡那霉素和氟苯尼考联合用药的急性毒效应评价
Evaluation of the Acute Toxic Effects of Combined Medication of Kanamycin Sulfate with Florfenicol
摘要
Abstract
In order to evaluate the clinical rationality of combined medication of kanamycin sulfate with florfenicol and to provide solid basis for further assessment of its safety indicators, the acute toxic effects of the combined medication of these two drugs on mice was investigated. The reported LD50 of kanamycin sulfate and florfenicol by intraperitoneal injection were 1 973.95 mg/kg and 636.68 mg/kg respectively, and the reported 95% confidence limit of kanamycin sulfate and florfenicol by intraperitoneal injection were 1 969.22-1 978.71 mg/kg and 538.5-735.1 mg/kg respectively. Based on these reported pharmacological parameters, the LD50 of combined medication of kanamycin sulfate with florfenicol was determined by equivalent diagram method. The results showed that in the combined medication, the LD50 of kanamycin sulfate by intraperitoneal injection in mice was 510.51 mg/kg and the 95%confidence limit ranged from 437.52 to 595.66 mg/kg;the LD50 of florfenicol by intraperitoneal injection in mice was 765.60 mg/kg and the 95%confidence limit ranged from 656.15 to 893.31 mg/kg. Furthermore, the intersection of LD50 dose line of combined medication of kanamycin sulfate and florfenicol fell outside the upper limit of 95% confidence limit, indicating that the combined medication of these two antibiotics produced antagonism of toxic effect. These results suggest the clinical rationality and reliability of combined medication of kanamycin sulfate with florfenicol.关键词
半数致死量/联合用药/硫酸卡那霉素/氟苯尼考Key words
LD50/drug combination/kanamycin sulfate/florfenicol分类
医药卫生引用本文复制引用
杨熠,高超,任丽娟,帕力达·亚森,马晓洋,米克热木·沙衣布扎提..硫酸卡那霉素和氟苯尼考联合用药的急性毒效应评价[J].畜牧与饲料科学,2016,37(3):7-10,4.基金项目
国家自然科学基金资助项目（31460677）。 （）
