生殖医学杂志2016，Vol.25Issue(4)：305-309,5.DOI:10.3969/j.issn.1004-3845.2016.04.003
两种卵泡刺激素在多囊卵巢综合征患者体外受精-胚胎移植中疗效比较
Comparison of clinical efficacy of two different FSH preparations in IVF-ET cycles in patients with polycystic ovarian syndrome
摘要
Abstract
Objective: To compare the treatment outcomes of two different FSH preparations in IVF-ET for patients with polycystic ovarian syndrome ( PCOS). <br> Methods: The clinical data of 130 anovulatory infertile women with PCOS undergone IVF-ET in our reproductive center from January 2013 to December 2014 were retrospectively analyzed. According to FSH preparation used for ovulation stimulation, the patients were divided into two groups:recombinant FSH ( rFSH, Gonal-F) group and high purity of urinary FSH ( uFSH-HP,Lishenbao) group. The dose of gonadotropin ( Gn) used,number of oocytes retrieved,the days of Gn used,mature oocyte rate,2PN rate,good embryo rate,frozen embryo rate,fresh embryo pregnancy rate,frozen embryos pregnancy rate,multiple pregnancy rate and severe ovarian hyperstimulation syndrome ( OHSS) incidence and the cost of Gn used. <br> Results: There were no significant differences in duration of controlled ovarian hyperstimulation ( COH) ,total dose of FSH used,oocytes retrieved rate,2PN rate,good-quality embryos rate,frozen embryos rate,fresh embryo pregnancy rate,frozen embryo pregnancy rate,OHSS incidence and multiple pregnancy rate between two groups ( P>0. 05). The rate of mature oocytes retrieved(80. 80% vs. 71. 20%) in uFSH-HP group was higher than that in rFSH group,but it was not significant (P>0. 05). The cost of Gn used in uFSH-HP group[(6 037±1 569)RMB vs. (9 049±1 332)RMB] was significantly lower than that in rFSH group (P<0. 01). <br> Conclusions: uFSH-HP can achieve similar COH efficacy and clinical outcomes as rFSH in IVF treatment, but it has an advantage of lower cost.关键词
体外受精-胚胎移植/多囊卵巢综合征/控制性促排卵/卵泡刺激素/临床妊娠率Key words
IVF-ET/Polycystic ovarian syndrome/Controlled ovarian hyperstimulation/FSH/Clinical pregnancy rate引用本文复制引用
徐鑫,李凌云,张静文,陈慧玲,刘永正,徐影..两种卵泡刺激素在多囊卵巢综合征患者体外受精-胚胎移植中疗效比较[J].生殖医学杂志,2016,25(4):305-309,5.基金项目
吉林省科技发展计划项目(20150311035YY) （20150311035YY）
