生殖医学杂志2016，Vol.25Issue(4)：310-314,5.DOI:10.3969/j.issn.1004-3845.2016.04.004
疑似异位妊娠腹腔镜手术后意外诊断的妊娠滋养细胞肿瘤患者的预后
Prognosis of gestational trophoblast neoplasia accidentally diagnosed by laparoscopy for a presumed ectopic pregnancy
摘要
Abstract
Objective: To investigate the prognosis of gestational trophoblast neoplasia ( GTN) diagnosed incidentally by laparoscopy for a presumed ectopic pregnancy. <br> Methods: Clinical data of the patients with GTN diagnosed incidentally after laparoscopy for a presumed ectopic pregnancy in Peking Union Medical College Hospital from Jan 2009 to Dec 2013 were analyzed retrospectively. <br> Results: Eleven patients were diagnosed as GTN based on postoperative pathology after laparoscopic lesion resection for a presumed ectopic pregnancy,including 5 patients with trophoblastic tumor ( PSTT) at placenta site,5 patients with choriocarcinoma and 1 patient with ectopic gestational choriocarcinoma. Of 11 patients, 9 patients received floxuridine (5-FuDR)-based multidrug chemotherapy and 2 received EMA/CO chemotherapy within 1-6 days [mean (1. 9±1. 6) days)] after surgery. In addition,3 patients underwent adjuvant hysterectomy combined with chemotherapy. The follow-up ( median 48 months,range 16-72 months) indicated that all patients achieved serum complete remission ( SCR) ,although one patient of PSTT had relapsed and ultimately achieved durable SCR by further salvage chemotherapy. <br> Conclusions: The clinical characteristics of GTN were very similar with ectopic pregnancy. After laparoscopic examination to confirm the diagnosis,GTN can be got an excellent prognosis through chemotherapy.关键词
异位妊娠/妊娠滋养细胞肿瘤/腹腔镜手术Key words
Gestational trophoblastic neoplasia/Laparoscopy/Diagnosis/Treatment引用本文复制引用
郭琦,冯凤芝,向阳,万希润,任彤..疑似异位妊娠腹腔镜手术后意外诊断的妊娠滋养细胞肿瘤患者的预后[J].生殖医学杂志,2016,25(4):310-314,5.基金项目
北京市科学技术委员会首都临床特色应用研究(Z131107002213173) （Z131107002213173）
