生殖医学杂志2016，Vol.25Issue(4)：320-324,5.DOI:10.3969/j.issn.1004-3845.2016.04.006
105例染色体多态性患者辅助生殖妊娠结局分析
Pregnancy outcome of 105 patients with chromosomal polymorphism after assisted reproductive technology
摘要
Abstract
Objective: To investigate the influence of chromosomal polymorphism on the pregnancy outcome of assisted reproductive technology ( ART). <br> Methods: All the patients undergone IVF or ICSI were randomly divided to two groups. The polymorphism group included 105 infertile couples,in whom at least one person of one couple had chromosomal polymorphism. The control group had 260 patients,and none of them had chromosomal polymorphism. The clinical outcomes were compared between the two groups. <br> Results: Primary infertility proportion in the polymorphism group is significantly higher than control group (63. 81% vs. 55. 00%,P<0. 05). Spontaneous abortion rate in polymorphism group is similar with control group (13. 16% vs. 12. 82%,P>0. 05). There were no significant differences in fertilization rate,good quality embryo rate,implantation rate,pregnancy rate,biochemical pregnancy rate,premature birth rate,sex ratio and descendant deformity rate of offspring between the two groups (all P>0. 05). The early miscarriage rate in polymorphism group was significantly higher than that of control group(33. 33% vs. 17. 40%,P<0. 05). <br> Conclusions: Chromosomal polymorphism does not have significant influence on the outcomes of ART,but it may increase the risk of early abortion.关键词
染色体多态性/辅助生殖/妊娠结局/早期流产率Key words
Chromosome polymorphism/ART/Pregnancy outcome/Early abortion rate引用本文复制引用
姜永辉,孔伟,宦晴,闻姬..105例染色体多态性患者辅助生殖妊娠结局分析[J].生殖医学杂志,2016,25(4):320-324,5.基金项目
山东省医药卫生科技发展计划项目(2014WS0165) （2014WS0165）
山东省科技发展计划项目(2014GSF118064) （2014GSF118064）
