生殖医学杂志2016，Vol.25Issue(4)：369-373,5.DOI:10.3969/j.issn.1004-3845.2016.04.016
睾丸间质干细胞分化和移植
Differentiation and transplantation of testicular Leydig stem cell
摘要
Abstract
Testicular Leydig cells are main cells which synthesize testosterone in male. Mesonephric stromal cells and fibroblast-like cells around seminiferous tubules are the stem Leydig cells ( SLCs ) during fetal development. In mammalian, the fetal Leydig cells ( FLCs ) are differentiated from SLCs at fetal stage. The neonate SLCs differentiated to the adult Leydig cells ( ALCs) via progenitor Leydig cells ( PLCs) , immature Leydig cells ( ILCs) . Testosterone production in Leydig cells decreases along with aging, while total number of Leydig cell may not changed. It was reported that marrow stromal cells ( MSCs) and adipose-derived stem cells, as well as some other stem cells, could be in vitro induced to differentiate to SLC with the function of testosterone production. SLCs transplantation could be a new method for clinical treatment of male hypogonadism and andropouse. The differentiation of SLCs and transplantation are reviewed in this paper.关键词
间质细胞/间质干细胞/雄激素/干细胞移植Key words
Leydig cell/Stem Leydig cell/Androgen/Stem cell transplantation引用本文复制引用
徐文丹,崔毓桂..睾丸间质干细胞分化和移植[J].生殖医学杂志,2016,25(4):369-373,5.基金项目
国家自然科学基金(81170559,81370754) （81170559,81370754）
江苏省卫生厅科教兴卫工程(ZX201110) （ZX201110）
