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胰岛素样肽3的功能及其研究进展

赵丽丽 聂敏 伍学焱

生殖医学杂志2016,Vol.25Issue(4):374-377,4.
生殖医学杂志2016,Vol.25Issue(4):374-377,4.DOI:10.3969/j.issn.1004-3845.2016.04.017

胰岛素样肽3的功能及其研究进展

Function insulin-like peptide 3 and its research progress

赵丽丽 1聂敏 1伍学焱1

作者信息

  • 1. 中国医学科学院,北京协和医学院,北京协和医院内分泌科,卫生部内分泌重点实验室,北京 100730
  • 折叠

摘要

Abstract

Insulin-like peptide 3 ( INSL3 ) is a gender-specific hormone. INSL3 level in human amniotic fluid is related to fetal gender. INSL3 levels increase firstly, and then decrease along with increased gestational age. The reduction of INSL3 levels may cause abnormality of testiculus gubernacular development, which may be one of the mechanisms for occurrence of cryptorchidism. Moreover, INSL3 can also maintain the survival of germ cell and regulate bone metabolism. The role of INSL3 in female is not yet clear. INSL3 can be used to evaluate the function of ovary, and it may regulate the synthesis of androgen. The paper reviews the function of INSLs in both of male and female and the research progress.

关键词

胰岛素样肽3/雄激素

Key words

Insulin-like peptide 3/Male/Females

引用本文复制引用

赵丽丽,聂敏,伍学焱..胰岛素样肽3的功能及其研究进展[J].生殖医学杂志,2016,25(4):374-377,4.

基金项目

国家自然科学基金(81270879) (81270879)

生殖医学杂志

OACSTPCD

1004-3845

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