生殖医学杂志2016，Vol.25Issue(4)：384-388,5.DOI:10.3969/j.issn.1004-3845.2016.04.019
促性腺激素释放激素拮抗剂在下丘脑垂体外生殖系统中的作用及临床应用
Effect of GnRH antagonist on extrapituitary tissues and its clinical application
摘要
Abstract
Recently, GnRH antagonists are commonly used in controlled ovarian stimulation ( COS ) for pituitary suppression. It can prevent early LH surge during COS to reduce cycle cancellation rate. GnRH and its receptors have been detected in numerous extrapituitary tissues. Because of the blockage of extrapituitary GnRH receptor by GnRH antagonists, GnRH antagonists can affect molecular and cellular events required for successful pregnancy,e. g. adequate follicular recruitment and maturation,and endometrial receptivity. However,there is no unified conclusion from related research. The exact effects of GnRH antagonists on extrapituitary tissues still need to be further studied,which may help to improve the result of clinical COS and the chance of embryo implantation.关键词
促性腺激素释放激素拮抗剂/垂体外组织/卵泡成熟/内膜容受性Key words
GnRH antagonist/Extrapituitary/Follicular maturation/Endometrial receptivity引用本文复制引用
陈骞..促性腺激素释放激素拮抗剂在下丘脑垂体外生殖系统中的作用及临床应用[J].生殖医学杂志,2016,25(4):384-388,5.基金项目
国家自然科学基金青年基金项目(81100469) （81100469）
