心理科学进展2016，Vol.24Issue(4)：525-535,11.DOI:10.3724/SP.J.1042.2016.00525
抑郁的多基因遗传基础
The polygenic underpinnings of depression
摘要
Abstract
Depression has highly complicated polygenic underpinnings that do not follow the law of Mendelian inheritance. However, existing research on the genetic mechanism of depression has primarily focused on the effects of single candidate genes. Recent studies using the method of polygenic risk scores and the gene by gene interactions approach have provided new evidence respectively for the existence of both additive genetic effects and interactive genetic effects on depression. These studies demonstrated that multi- genes interact with environmental factors in their effects on the etiology of depression, and gender has a strong influence on these interactions. It is assumed that the effects of multi-genes on depression would be possibly mediated by the specific endophenotypes, such as cognitive factors, personality and stress hormone. Future research in this realm should pay greater attention to the interactions between multi-genes and multi-environments, gender differences in the polygenic underpinnings and the dynamic changes in polygenic effects over development.关键词
抑郁/多基因遗传/内表型/性别差异Key words
depression/polygenic/endophenotypes/gender difference分类
社会科学引用本文复制引用
曹衍淼,王美萍,曹丛,张文新..抑郁的多基因遗传基础[J].心理科学进展,2016,24(4):525-535,11.基金项目
国家自然科学基金项目(31271105)、高等学校博士学科点专项科研基金项目(20133704110001)。 （31271105）
