心理科学进展2016，Vol.24Issue(4)：536-546,11.DOI:10.3724/SP.J.1042.2016.00536
创伤后应激障碍患者的HPA轴功能变化的时间序列特征
Temporal characteristics of change in HPA activity among PTSD patients
摘要
Abstract
Posttraumatic stress disorder (PTSD) is associated with abnormal functioning of the hypothalamic- pituitary-adrenocortical (HPA) axis, as shown by alterations of cortisol levels. However, results on the link of cortisol level with PTSD are inconsistent. Recent studies imply that PTSD patients show temporal characteristics of the change in cortisol level with the elevation at early stage and thereafter the decrease relative to the normal basal cortisol level after traumatic exposure. The temporal characteristics might be disturbed or masked by some factors, such as characteristics of biomarker, course of PTSD, type and intensity of stressor and comorbid disease. The present review suggested that future research needs to further profile temporal characteristics of change in cortisol level among PTSD patients by controlling the influencing factors and utilizing long-term follow-up design in combination with acute-stress and chronic- stress biomarkers and investigate whether it can be used to predict and intervene PTSD through cortisol treatment. Considering that cortisol level is regulated by metabolism and antagonism procedures, the use of multi-biomarkers will facilitate the reliable evaluation of the HPA axis activity among PTSD patients.关键词
创伤后应激障碍/皮质醇/HPA轴/时间序列特征Key words
posttraumatic stress disorder/cortisol/hypothalamic-pituitary-adrenocortical (HPA) axis/temporal characteristics分类
社会科学引用本文复制引用
张权,陈崝,王玮文,邓慧华..创伤后应激障碍患者的HPA轴功能变化的时间序列特征[J].心理科学进展,2016,24(4):536-546,11.基金项目
中国科学院心理健康重点实验室开放课题基金重点项目 （）
江苏省普通高校研究生科研创新计划项目(KYZZ15_0054和 KYZZ14_0069) （KYZZ15_0054和 KYZZ14_0069）
中央高校基本科研业务费专项资金资助。 （）
