新医学2016，Vol.47Issue(4)：237-241,5.DOI:10.3969/j.issn.0253-9802.2016.04.008
干燥综合征诊断的无创性分类标准研究
Study of non-invasive score classification criteria in diagnosis of Sjgren’s syndrome
摘要
Abstract
Objective Tocomparetheclinicalvaluesamongnon-invasivescore(NIS),American-European Consensus Group's classification criteria (AECG,2002)and labial salivary gland biopsy (LSGB)in thediagnosisofSjgren'ssyndrome(SS).Methods Clinicaldataof76casessuspectedwithSSwerecollect-ed. NIS and AECG classification criteria were utilized for the diagnosis of SS,which was further validated by ocular and oral symptoms,physical signs,autoantibodies,positive LSGB outcomes and subsequent follow-up.ThediagnosticvaluesofNIS,AECGandLSGBwerestatisticallycompared.Results Among76patientssus-pected with SS,42 were definitely diagnosed with SS. Ocular and oral symptoms,corneal fluorescent staining, histopathological findings,physical signs,positive rate of complicated with autoimmune thyroid disorders signif-icantly differed (all P<0.05 ),whereas Schirmer'sⅠtest and autoantibodies did not considerably differ be-tween SS patients and healthy counterparts (both P>0.05 ). Among the 42 SS patients,there were 36 patients had NIS score >4,1 with NIS score <4,and 5 with NIS score=4 (totally 1 6 with NIS score=4,6 with positive LSGB and 5 with SS,1 0 with negative LSGB and none with SS). The sensitivity and specificity for the NIS classification criteria were 97.6%and 94.1%in the diagnosis of SS. The negative and positive predictive values were 97.0% and 95.3%,and the diagnostic accuracy was 96.1%. The area under the ROC curves for NIS classification criteria was 0.959 (0.905-1.000),significantly higher compared with those for the AECG classificationcriteriaandLSGB(bothP<0.05).Conclusions NISclassificationcriterionyieldshigherac-curacy than AECG in the diagnosis of SS. NIS score of 4 acts as the cut-off value for the diagnosis of SS. For patients with NIS score<4,LSGB is recommended to confirm the diagnosis.关键词
干燥综合征/分类标准/诊断/无创性/积分Key words
Sjgren'ssyndrome/Classificationcriteria/Diagnosis/Non-invasive/Score引用本文复制引用
余金泉,陈冬莹,张丽君,谢燕,詹钟平..干燥综合征诊断的无创性分类标准研究[J].新医学,2016,47(4):237-241,5.基金项目
广东省科技计划项目（2012B031800375，2012B031800457，2014A020221009）；广东省医学科学基金 （）
