摘要
Abstract
Objective To investigate the relationship between the serum levels of EVPWI in patients with severe pneumonia and the plasma soluble triggering receptor-1 (sTREM-1).Methods A total of 32 cases of patients with severe pneu-monia from February 2012 to May 2015 at Guangdong Medical College Affiliated Hospital were enrolled, they were divided ac-cording to 28 day prognosis into survival group ( n =23) and death group ( n =9), dynamic monitoring patients in ICU 1, 3, 5 day’s EVLWI and pulmonary microvascular permeability determination (PVPI) and changes of plasma sTREM-1 level. Analysis EVLWI and PVPI and plasma sTREM-1 level’ s correlation.Results Patients with severe pneumonia, death and survival group had no significant difference ( P >0 05) of first day ICU admission’ s EVLWI, PVPI, sTREM-1 level; the survival group’s plasma EVLWI, PVPI, sTREM-1 level in the first and third, fifth days gradually decreased ( P <0.05), whereas no significant fluctuations in the death group ( P >0.05); at third, fifth days, death group’ s EVLWI, sTREM-1 levels were significantly higher than the survival group ( P <0.05), the fifth day’s PVPI was significantly higher than surviv-al group ( P <0 05.); EVLWI, PVPI and sTREM-1 levels were significantly correlated ( r =0.457, r =0.412, P <0.05).Conclusion PVPI, EVLWI can indirectly reflect the level of inflammatory factors in patients with severe pneumonia, help to assess the condition of patients with severe pneumonia.关键词
重症肺炎/血管外肺水指数/可溶性髓样细胞触发受体-1Key words
Severe pneumonia/Extravascular lung water index/Soluble triggering receptor expressed on myeloid ceils-1
